Vitamin Supplement for Dialysis Patients +
The worlds most complete dialysis vitamin.
All of the same ingredients in standard Renal Vitamins PLUS:
Zinc-Oxide for Immune support
L-Carnitine for Muscles, Energy and Anemia support
Nephrologist Invented, Supported by Science, Guideline Based
We can all use a Boost!
From Dr. Barry:
For years I’ve been researching ways to improve my patients symptoms on dialysis. If you look carefully at the research, guidelines and expert opinions below you can see common themes. The water soluble vitamins are washed out, L-Carnitine is lost, zinc intake in dialysis patients is low, and antioxidants vitamin C and E are essential.
In the past we would piece meal these recommendations, take a renal vitamin, take Vitamin E, also take a C supplement, find L-Carnitine and take that and add zinc to your regimen.
It’s way to complicated, expensive, confusing and our patients swallow enough pills as it is.
DialysisAide was born. All the water soluble vitamins in a standard renal vitamin plus the key Vitamins E, C, Zinc, and muscle centric Amino Acid L-Carnitine together in 1 bottle. Just 2 easy swallow capsules a day. Read more below.
Many patients on Dialysis:
- Get cramps
- Feel drained especially after the session
- Have diminished immune systems.
In fact Dialysis washes out many vital nutrients including all of the water soluble vitamins like Vitamin C, Niacin, Thiamine, Riboflavin, B6 and B12.
Dialysis also drains the body of the water soluble muscle centric essential amino acid L-Carnitine.
L-Carnitine is a small water soluble amino acid that has an essential role in fatty acid metabolism in skeletal muscle.
Carnitine can be measured in the blood with a simple laboratory test.
Carnitie is mostly derived from dietary meat consumption with a small percent biosynthesized in the kidney and liver.
In the healthy general population Carnitine deficiency is quite rare.
In the dialysis population, Carnitine deficiency is exceedingly common, we just don’t often test for it (at least not in the United States).
It has been shown that up to 70% of free Carnitine is dialyzed off in a single dialysis session.
Dialysis patients are often on dietary restrictions and of course the kidneys are unable to biosynthesize Carnitine any longer.1,3
Carnitine Deficiency Symptoms Include
- Anemia that is resistant to our standard EPO treatments
- Muscular weakness
- Cardiac dysfunction
- Low exercise capacity
- Low Blood pressure on dialysis1,3
*DialysisAide contains 500 mg of L-Carnitine per serving.
Get out of the Dialysis fog and get back to feeling good again.
What Patients are Saying
What the Experts are Saying
National Kidney Foundation KDOQI Guidelines state
CKD: Micronutrient Supplementation, Dialysis
In adults with CKD 5D who exhibit inadequate dietary intake for sustained periods of time, it is reasonable to consider supplementation with multivitamins, including all the water-soluble vitamins, and essential trace elements to prevent or treat micronutrient deficiencies (OPINION).
“Most Studies of subjective symptoms [muscle weakness, low energy, cramping] with L-Carnitine supplementation show a beneficial effect. They go on to state “Several members of the work group , felt that a short term trial of L-Carnitine was reasonable in selected patients with these symptoms who are unresponsive to other therapies.”2
Also stated “members of the work group believe a trial of L-carnitine is reasonable in selected patients with anemia and/or large erythropoietin requirements”.2
American Association of Kidney Patients
Panel recommended Carnitine treatment for certain conditions in dialysis patients who do not adequately respond to standard therapy:
- muscle cramps and hypotension
- lack of energy
- skeletal muscle weakness and/or myopathy
- anemia or uremia unresponsive to or requiring large doses of erythropoietin.3
CMS states for L-Carnitine supplementation approval:
Patients must have Carnitine deficiency on blood work <40 micromol/L + signs and symptoms of L-Carnitine Deficiency which include:
- Treatment Resistant Anemia
- Low Blood pressure on Dialysis
In fact it was on December 15th, 1999 the IV form was approved for these conditions
European Best Practice Guidelines state
A daily supplement of 400-800 IU is recommended in secondary prevention of cardiovascular events and for preventing recurrent muscle cramps for dialysis patients.
In a head to head trial Dialysis patients taking Vitamin E 400 IU at bedtime showed a ~70% reduction in leg cramps. The authors conclude that Vitamin E is recommended for patients on dialysis with leg cramps.7
Severe zinc deficiency depresses immune function, and even mild to moderate degrees of zinc deficiency can impair macrophage and neutrophil functions, natural killer cell activity, and complement activity. The body requires zinc to develop and activate T-lymphocytes. Individuals with low zinc levels have shown adverse alterations in immunity that can be corrected by zinc supplementation. These alterations in immune function might explain why low zinc status has been associated with increased susceptibility to pneumonia and other infections.8
European Best Practice Guidelines state
A zinc supplement of 50 mg per day for 3-6 months should be considered in hemodialysis patients.4
Symptoms linked to zinc deficiency include:
- impaired taste or smell
- skin fragility
- peripheral neuropathy
Also noted in a recent randomized control trial of Hemodialysis patients who were zinc deficient, supplementing Zinc improved Erythropoietin responsiveness. The authors concluded “zinc supplementation may be a useful therapeutic strategy for renal anemia treatment in patients undergoing Hemodialysis and with low serum zinc levels.”9
KDOQI Guideline 2020
CKD: Vitamin C Supplementation
In adults with CKD 1-5D or post transplantation who are at risk of Vitamin C deficiency it is reasonable to consider supplementation to meet the recommended intake of at least 90 mg/d for men and 75 mg/d for women (OPINION).
A randomized double blinded placebo controlled trial in 40 dialysis patients over 8 weeks comparing Vitamin E, Vitamin C, the combination of the 2 vs placebo took place. In this study cramping frequency decreased by 97% in the combination C and E group vs only 7% in the placebo group.10
Vitamin C (ascorbic acid) is a nutrient your body needs to form blood vessels, cartilage, muscle and collagen in bones. Vitamin C is also vital to your body’s healing process.
Vitamin C is an antioxidant that helps protect your cells against the effects of free radicals — molecules produced when your body breaks down food or is exposed to tobacco smoke and radiation from the sun, X-rays or other sources. Free radicals might play a role in heart disease, cancer and other diseases. Vitamin C also helps your body absorb and store iron.6
Vitamin C is found in fruits and vegetables. Often times unfortunately these foods may be restricted due to concerns over potassium content. It has been shown that 30-40% of Vitamin C is removed by dialysis in a single session.
|DialysisAide||Standard Dialysis Vitamin|
|Vitamin B1||Vitamin B1|
|Vitamin B2||Vitamin B2|
|Vitamin B3||Vitamine B3|
|Vitamin B4||Vitamin B4|
|Vitamin B5||Vitamin B5|
|Vitamin B6||Vitamin B6|
|Vitamin B12||Vitamin B12|
|Vitamin C||Vitamin C|
- Front. Med., 05 November 2021 | https://doi.org/10.3389/fmed.2021.767945
- KDOQI Clinical Practice Guidelines for Nutrition in Chronic Renal Failure Appendix X
- CMS.Gov Levocarnitine for End Stage Renal Disease
- European Best Practice Guidelines on Nutrition in Dialysis. Nephrol Dial Transplant (2007) 22 [Suppl 2]: ii45–ii87 doi:10.1093/ndt/gfm020
- Mayo Clinic Vitamin C online accessed February 2022
- NIH Dietary Supplement Vitamin C online accessed February 2022
- Roca AO, Jarjoura D, Blend D, Cugino A, Rutecki GW, Nuchikat PS, Whittier FC. Dialysis leg cramps. Efficacy of quinine versus vitamin E. ASAIO J. 1992 Jul-Sep;38(3):M481-5. PMID: 1457907.
- NIH dietary Supplement Zinc online accessed March 2022
- Oral Zinc Supplementation Reduces the Erythropoietin Responsiveness Index in Patients on Hemodialysis. Nutrients. 2015 May; 7(5): 3783–3795.
- Khajehdehi P, Mojerlou M, Behzadi S, Rais-Jalali GA. A randomized, double-blind, placebo-controlled trial of supplementary vitamins E, C and their combination for treatment of haemodialysis cramps. Nephrol Dial Transplant. 2001 Jul;16(7):1448-51. doi: 10.1093/ndt/16.7.1448. PMID: 11427639.
Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.